The AI Revolution in Saudi Arabia: How Generative AI is Reshaping Key Industries

Mar 25, 2025

Kholoud Hussein 

 

Generative Artificial Intelligence (GenAI) is rapidly transforming industries worldwide, and Saudi Arabia is embracing this technological revolution with strategic vigor. Aligned with the Kingdom's Vision 2030 initiative to diversify its economy beyond oil dependence, GenAI is making significant inroads into various sectors, particularly within the private domain and the burgeoning startup ecosystem. This article explores the sectors most impacted by GenAI in Saudi Arabia, supported by recent data and insights from industry leaders, and discusses potential sectors poised for future transformation.

 

The Rise of GenAI in Saudi Arabia

Under the ambitious leadership of Crown Prince Mohammed bin Salman, Saudi Arabia is positioning itself as a global hub for artificial intelligence. The Kingdom's strategic initiatives, such as "Project Transcendence," aim to attract substantial investments from global tech companies to bolster domestic AI infrastructure, including data centers and startups. This aligns with the broader Vision 2030 plan to diversify the economy and reduce dependence on oil. 

 

The Public Investment Fund (PIF) has announced plans to launch a $40 billion fund to invest in AI, potentially partnering with venture capital firms like Andreessen Horowitz. This initiative underscores the Kingdom's commitment to establishing a robust AI ecosystem, fostering innovation, and attracting global tech leaders to its domestic market. 

 

Sectors Most Affected by GenAI

1. Technology Sector

The technology sector stands at the forefront of GenAI adoption in Saudi Arabia. According to research by Strategy& Middle East, the sector could see an increase in operating profit by up to SAR 15 billion by 2028 through the development and commercialization of new GenAI use cases and the growing demand for advanced hardware and infrastructure. Additionally, Saudi tech firms could streamline their research and development (R&D) capabilities, enhance solution design, and automate internal processes, potentially reducing costs by up to 30%. 

 

2. Media and Entertainment

The media and entertainment sector is poised to benefit significantly from GenAI. The same Strategy& report indicates that this sector could experience an increase in operating profit of up to SAR 6 billion by 2028. GenAI enables firms to develop more original Arabic content, personalize customer experiences, and improve operational capabilities. This advancement aligns with the Kingdom's national agenda to establish itself as a media and entertainment hub. 

 

3. Telecommunications

Telecommunications companies in Saudi Arabia are leveraging GenAI to enhance customer insights and infrastructure utilization. The adoption of GenAI could lead to an increase in operating profit of up to SAR 11 billion by 2028. By analyzing customer behavior, telecom operators can personalize campaigns and enhance cross-selling opportunities, particularly within the small and medium-sized enterprises (SME) market, projected to reach SAR 10 billion by 2028. 

 

4. Healthcare

The healthcare sector in Saudi Arabia is also experiencing the transformative effects of GenAI. Globally, AI is being utilized for predictive diagnostics, personalized treatment plans, and efficient patient management. In Saudi Arabia, integrating GenAI could enhance healthcare delivery, optimize resource allocation, and improve patient outcomes, aligning with the Kingdom's goals to modernize its healthcare infrastructure.

 

5. Finance and Banking

The finance and banking sector is transforming with the integration of GenAI. AI-driven algorithms are enhancing fraud detection, risk assessment, and customer service through chatbots and personalized financial advice. Saudi banks and financial institutions are investing in AI technologies to streamline operations, reduce costs, and offer innovative services to customers.

 

Impact on Startups and the Private Sector

The startup ecosystem in Saudi Arabia is rapidly evolving, with a significant focus on deep tech innovations. A report by the Ministry of Communications and Information Technology, in collaboration with King Abdullah University of Science and Technology, reveals that up to 50% of deep tech startups in the Kingdom are working on artificial intelligence and the Internet of Things (IoT). These startups have collectively secured more than $987 million in funding, reflecting a robust commitment to technological advancement.

 

The number of active startup investors in Saudi Arabia reached 104 in 2023, marking a 41% increase from 2018. Public funds heavily support this expansion, as the government is committed to nurturing tech startups and scale-ups. Furthermore, the number of researchers in the country has risen by 75% since 2015, with plans to expand the research infrastructure to accommodate 140,000 researchers by 2030, up from the current 20,000.

 

Insights from Saudi Officials and Business Leaders

Saudi officials and business leaders are vocal about the transformative potential of GenAI. Richard Attias, CEO of the Future Investment Initiative (FII) Institute, emphasizes the importance of AI in addressing global challenges and fostering inclusive investments. He highlights the role of AI in driving innovation and efficiency across various sectors, aligning with the Kingdom's vision for economic diversification. 

 

The Kingdom's strategic collaborations, such as the partnership between Aramco and Groq to build the world's largest AI inference data center, underscore the commitment to establishing a robust AI infrastructure. These initiatives are part of a broader strategy to position Saudi Arabia as a leader in AI investment, complementing the country's oil wealth and ensuring relevance in the post-oil era. 

 

Potential Sectors for Future GenAI Impact

Beyond the sectors currently experiencing significant GenAI integration, several other industries in Saudi Arabia are poised for transformation in the near future. As the Kingdom continues its AI-driven economic diversification, the following sectors are expected to see increasing disruption and opportunities for growth.

 

1. Automotive Industry

Saudi Arabia’s ambitious plans to establish a homegrown automotive industry, with initiatives such as Ceer Motors, will likely benefit from GenAI. Generative AI can revolutionize vehicle design, predictive maintenance, and supply chain optimization.

  • Generative Design: AI can optimize vehicle components for strength, weight, and fuel efficiency, improving performance and reducing material waste.
  • Smart Manufacturing: AI-powered automation in assembly lines can enhance precision and efficiency while lowering production costs.
  • Autonomous Vehicles: As part of the Kingdom’s Vision 2030 Smart City initiatives (such as NEOM and The Line), GenAI will play a key role in self-driving technology, traffic management, and mobility solutions.

With the Saudi government investing billions into electric and autonomous vehicles, this sector is primed for AI-driven innovation.

 

2. Education and E-Learning

Saudi Arabia has been actively integrating AI into education, with a strong push toward personalized learning experiences and AI-powered content generation.

  • Adaptive Learning Platforms: AI can tailor lessons to individual student needs, ensuring better retention and engagement.
  • Automated Content Generation: GenAI tools can develop course materials, summarize lectures, and even generate interactive quizzes.
  • AI-powered tutoring: Chatbots and AI tutors can provide 24/7 academic support to students across various disciplines.

With the Kingdom investing heavily in digital education platforms, GenAI could redefine the way students and professionals learn in Saudi Arabia.

 

3. Real Estate and Urban Development

The Saudi real estate sector is undergoing rapid expansion, driven by mega-projects like NEOM, Qiddiya, and the Red Sea Project. AI is expected to streamline construction planning, optimize resource allocation, and enhance property management.

  • AI-Generated Architectural Designs: Generative AI can automate building designs, improving efficiency and reducing project timelines.
  • Smart Cities: AI-driven traffic control, energy management, and security systems will play a crucial role in urban development.
  • Property Valuation and Market Predictions: AI-powered analytics can provide accurate real estate forecasts, assisting investors and developers in making informed decisions.

As Saudi Arabia aims to create futuristic, AI-driven urban environments, GenAI will be integral to shaping the Kingdom’s real estate landscape.

 

4. Retail and E-Commerce

Saudi Arabia’s booming e-commerce market, projected to reach $20 billion by 2025, is already leveraging AI for customer experience enhancement and supply chain optimization.

  • Hyper-Personalized Shopping: AI can analyze customer behavior and generate real-time personalized recommendations.
  • AI-powered chatbots: Virtual assistants can handle customer inquiries, recommend products, and process transactions, improving efficiency.
  • Inventory and Logistics Optimization: AI models can predict demand trends, automate restocking, and reduce waste, making supply chains more efficient.

With Saudi startups and enterprises investing heavily in AI-driven retail solutions, the sector is poised for even greater transformation in the near future.

 

5. Energy and Sustainability

As Saudi Arabia transitions toward renewable energy and sustainability goals, GenAI will play a pivotal role in optimizing energy management and reducing carbon footprints.

  • AI-Optimized Power Grids: Machine learning algorithms can predict energy demand, allowing for efficient power distribution.
  • Predictive Maintenance for Renewable Energy: AI can monitor and predict failures in solar farms, wind turbines, and smart grids, reducing downtime and maintenance costs.
  • Sustainable Resource Allocation: AI-driven simulations can optimize water and energy usage across industrial and residential sectors.

Saudi Arabia’s commitment to green energy through projects like the $5 billion NEOM Green Hydrogen plant highlights GenAI's crucial role in the energy sector.

 

Finally, Generative AI is fundamentally reshaping industries across Saudi Arabia, accelerating economic diversification and boosting productivity. While sectors like technology, media, telecommunications, healthcare, and finance have already witnessed significant AI integration, emerging fields like automotive, education, real estate, retail, and energy are set to experience profound transformations.

 

With the Saudi government investing in AI research, local startups, and global partnerships, the Kingdom is on track to become a global AI hub. However, challenges remain in terms of regulation, talent development, and infrastructure, which must be addressed to fully capitalize on GenAI’s potential.

 

As Saudi Arabia continues its digital revolution, AI-powered industries will drive innovation, economic growth, and long-term sustainability, positioning the Kingdom as a leader in the global AI economy.

 

 

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Saudi resale revolution: how secondhand market is reshaping e-commerce

Noha Gad

 

The e-commerce sector in Saudi Arabia has settled into a stable, high-growth era, driven by increased opportunities for e-commerce players and a continued rise in consumer preference for innovative new payment methods, ranging from Buy Now, Pay Later (BNPL) to crypto and digital wallets. According to the latest report released by the Ministry of Commerce, the e-commerce sector experienced a 5% increase in existing registrations during the third quarter (Q3) of 2025, reaching 41,816 registrations, compared with 39,769 in Q3-24. Another report published by Modor Intelligent indicated that the e-commerce market size in Saudi Arabia reached $27.9 billion in 2025, and is projected to grow at a compound annual growth rate (CAGR) of 11.9% between 2026 and 2031. The re-commerce sector emerged rapidly across the Kingdom, transforming the way consumers buy and sell pre-owned goods. Fueled by a large, connected youth population and a booming e-commerce ecosystem, buying and selling pre-owned goods through specialized applications and online platforms moved from a niche practice to a mainstream economic activity. 

Digital marketplaces are redefining value for Saudi consumers, offering access to high-quality secondhand electronics, fashion, furniture, vehicles, and real estate units with unprecedented convenience and security. This tech-driven sector not only unlocks significant economic value for individuals and entrepreneurs but also aligns with national priorities by promoting a more circular economy and sustainable consumption patterns in alignment with Vision 2030.

Resale in Saudi Arabia primarily refers to the informal buying and selling of pre-owned goods through digital platforms, such as Haraj, Soum, Kayishha, Syarah, Dubizzle, and OpenSooq, where transactions rely on personal trust, direct negotiation, and minimal platform intervention. This model dominates for everyday items, such as used furniture, cars, and mid-range fashion, often lacking formal quality checks or warranties.

The re-commerce market in Saudi Arabia is expected to grow annually by 15.8% to record $1.75 billion in 2025. According to a recent report published by ResearchAndMarkets, the market is expected to grow at a CAGR of 13.3% between 2025 and 2029 to reach $2.88 billion by the end of 2029. This growth will be fueled by a mix of economic drivers, policy support, and digital infrastructure and payment readiness

Rising living costs amid aspirational spending made pre-owned goods a practical choice for electronics, fashion, and appliances, especially as new luxury items strain budgets for the Kingdom's young urban professionals. This shift is evident in the rapid growth of electronics trade-ins and fashion resale, where affordability meets desire without compromising perceived quality. Additionally, re-commerce aligns perfectly with Vision 2030’s circular economy targets by extending product lifecycles, appealing to a rising eco-conscious demographic that views resale as both sustainable and patriotic.

High smartphone penetration, advanced logistics, and widespread digital wallets enabled key players in the Saudi market to offer seamless transactions. Trust mechanisms such as escrow, buyer protection, and cash-on-delivery (COD) options bridge cultural preferences for secure deals. This infrastructure, combined with social media's influence, accelerates peer-to-peer (P2P) and B2C models, making Saudi Arabia a frontrunner in regional re-commerce maturity.

Saudis have long embraced resale through trusted informal channels, but digital platforms now focus on structure, quality assurance, and scale to evolve the market.

 

Key players in the Saudi market

  • Haraj: Established in 2007, Haraj is a Saudi marketplace for all goods, cars, real estate, and electronics. It initially focused on cars, then moved to real estate, and ended up being the one-stop shop for all classifieds in the Kingdom. Receiving over half a million visitors daily, Haraj applies the world's latest technologies at the back-end to provide developers with a great environment to learn and empower entrepreneurs to build a strong base before expanding the market.
  • Soum: One of the leading marketplaces for secondhand electronics in Saudi Arabia that enables users to buy, sell, and discover various products, including desktops, laptops, tablets, smartwatches, cameras, headphones, and more. This first-of-its-kind unified national application enables both small and medium-sized enterprises (SMEs) and individuals to sell in its marketplace, leveraging its wide network that covers over 150 Saudi cities.
  • Kayishha: A reliable car buying company in Saudi Arabia that helps car sellers sell their used cars in a hassle-free manner, regardless of their make, model, age, or condition. Using a safe and transparent car-selling process, Kayishha enables sellers to sell their cars in just 30 minutes.
  • OpenSooq: The leading mobile-first classifieds marketplace in the Middle East and North Africa (MENA) region that allows users to buy, sell, and trade a wide variety of goods and services. It enables user-to-user real-time chat and allows each user to build their own profile.

 

Saudi consumer engagement with the resale market is a significant and growing trend, primarily driven by a generational shift where younger buyers prioritize value and sustainability over pristine newness. Tech-savvy youth are the primary adopters of digital resale platforms, using them for value-driven purchases and to generate side income. In the context of high costs for new vehicles, electronics, and branded goods, the resale market serves as a strategic channel for cost-conscious consumers to access quality products. However, quality and counterfeiting fears persist, particularly for fashion and tech. 

The resale market in the Kingdom faces several distinct challenges that affect its scalability, trust, and user experience. Major challenges include:

  • Lack of standardization: In open-market platforms, product grading, condition descriptions, and imagery are not standardized, leading to buyer-seller disputes and hesitation.
  • Counterfeit and misrepresented goods: Particularly in high-value segments like luxury fashion, electronics, and automotive parts, verifying authenticity and accurate condition descriptions remains a significant hurdle.
  • Seller accountability: Ensuring reliable seller behavior, honest representation, and safe transaction completion can be difficult on P2P platforms without robust mediation systems.
  • Returns and refunds complexity: Establishing fair and clear return policies for used items is a persistent operational and customer service challenge.
  • Consumer protection gaps: The legal framework for disputes in private online sales is less clear than for registered e-commerce businesses, potentially leaving buyers and sellers vulnerable.

Additionally, challenges center on building systematic trust, streamlining complex operations, and changing deep-seated consumer habits. Addressing these issues through technology, standardized services, and clear regulations is instrumental for the Saudi resale market to mature from a popular informal exchange into a structured, high-growth segment of the retail economy.

Finally, Saudi Arabia’s e-commerce landscape is advancing on two dynamic fronts: the mature expansion of traditional e-commerce and the rapid emergence of re-commerce. Together, they are fundamentally reshaping the Kingdom’s retail economy, driven by digital adoption, youthful demographics, and alignment with Vision 2030's economic diversification and sustainability goals. The re-commerce sector evolved from informal P2P trading into a structured, high-potential market projected for significant growth. Digital marketplaces are driving this shift, moving the market toward greater convenience, trust, and scale. As these marketplaces continue to innovate and integrate stronger trust mechanisms, they will not only capture greater market share but also redefine sustainable consumption for a generation.

How Startups Can Use Gamification to Supercharge Their Marketing

Ghada Ismail

 

In a competitive digital landscape, grabbing attention and keeping users engaged is tougher than ever. Traditional marketing tactics alone often fall short in capturing long-term interest. This is where gamification—the practice of applying game mechanics to non-game experiences—comes in. By making interactions fun, interactive, and rewarding, gamification transforms ordinary campaigns into experiences that motivate, engage, and create loyalty.

 

What is Gamification?

Gamification involves integrating elements like points, badges, levels, challenges, leaderboards, and rewards into marketing, apps, or digital platforms. It leverages human psychology by tapping into natural drivers such as achievement, progress, recognition, and competition. When users feel motivated by these triggers, they are more likely to take the actions you want as a business owner, including signing up, sharing content, purchasing, or returning regularly. In short, gamification is about making engagement both enjoyable and purposeful.

 

1. Understand Your Audience

Not all users respond to the same incentives. Some are motivated by competition and social recognition, while others seek personal achievement, mastery, or tangible rewards. Startups need to research and segment their audience to understand these motivations. By aligning gamification mechanics with user preferences, you create experiences that feel meaningful rather than gimmicky, increasing the likelihood of consistent engagement.

 

2. Set Clear Objectives

Gamification should be integrated into a broader marketing strategy, not treated as a standalone tactic. Every gamified element should tie back to specific business goals. For example, if your aim is to grow your email list, the gamification should reward sign-ups or referrals. If your goal is repeat purchases, points, or progress tracking tied to buying behavior can encourage loyalty. Clearly defined objectives also allow you to measure success, adjust strategies, and ensure your gamification delivers tangible results.

 

3. Incorporate Game Mechanics Thoughtfully

Choosing the right mechanics is essential. Gamification tools like points, badges, levels, challenges, leaderboards, and progress bars can all enhance engagement, but only if they are implemented thoughtfully. Points and rewards incentivize specific actions, while badges and levels recognize achievement and create a sense of progress. Leaderboards foster healthy competition, challenges encourage ongoing interaction, and progress bars visually track advancement, keeping users motivated and invested over time.

 

4. Make It Social and Shareable

Humans are inherently social creatures, and gamification thrives on social interaction. When users can share achievements, invite friends, or compete with peers, engagement naturally increases. Social features also amplify the reach of your campaigns, turning users into organic promoters of your brand. Encouraging friendly competition or cooperative challenges can transform a passive marketing experience into an interactive, community-driven journey.

 

5. Tie Rewards to Real Value

Rewards are only effective when they feel worthwhile. They don’t always need to be financial; recognition, early access, exclusive content, or digital perks can be equally compelling. The key is that rewards align with user interests and reinforce desired behaviors. When users perceive genuine value in the rewards, they are more likely to participate and remain engaged.

 

6. Test, Measure, and Iterate

Gamification is not one-size-fits-all. Continuous monitoring, testing, and refinement are essential to maintain effectiveness. Startups should track engagement metrics, experiment with different mechanics, and respond to user feedback. Iteration ensures that gamified experiences evolve alongside user behavior and market trends, keeping your marketing strategy relevant and impactful.

 

Wrapping Things Up…

Gamification can transform traditional marketing into interactive, engaging experiences that drive meaningful actions and foster loyalty. For startups, it offers a cost-effective way to increase user engagement, encourage repeat interactions, and differentiate your brand. By focusing on audience motivations, setting clear goals, thoughtfully implementing game mechanics, creating social interactions, providing meaningful rewards, and iterating based on feedback, startups can use gamification to deliver campaigns that are both fun and results-driven.

Unlocking startup profits: master MROI to turn marketing spend into growth

Noha Gad

 

Startups often struggle with limited budgets while pursuing rapid growth, relying on lean marketing approaches such as growth hacking, content marketing, and digital channels to maximize revenues. These strategies prioritize low-cost, high-impact tactics such as social media virality, SEO-driven inbound leads, and influencer partnerships over traditional mass advertising. Therefore, marketing return on investment (MROI) became crucial as it evaluates how effectively these efforts translate spending into profitable revenue.

 

What is marketing ROI?

Marketing ROI is a performance measure used to evaluate the efficiency of a marketing campaign or to compare the efficiency of different campaigns, helping marketers understand what is working, what is not, and where to adjust. It is a critical metric for proving marketing’s impact on growth and making smarter budget decisions.

It refers to all profit and revenue growth from all marketing channels, which may include email marketing, social media marketing, digital marketing, and any other type of marketing.

MROI contributes to assessing broader value, such as customer engagement, brand visibility, and long-term impact, by evaluating how different channels and campaign types boost business growth. It also helps startups build a strategy that delivers both short-term results and long-term gains.

 

Marketing ROI = (Revenue Generated from Marketing - Cost of Marketing) / Cost of Marketing 

 

Startups and companies can track marketing ROI by evaluating the cost ratio or efficiency ratio. This formula calculates how much money is generated for every marketing dollar spent. An efficient marketing campaign may result in a cost ratio of 5:1—that is, $5 generated for every $1 spent, with a simple marketing ROI of 400%. 

Early-stage companies typically aim for MROI benchmarks of 3:1 to 5:1, adapting as they scale from acquisition-focused tactics to retention-driven models. It shifts focus from vanity metrics, such as impressions, to revenue realities, enabling data-backed pivots in volatile markets. 

 

Marketing ROI vs. traditional ROI

MROI fundamentally differs from traditional ROI in accounting terms due to the way each is classified and treated on financial statements. Traditional ROI applies to capital expenditures (CAPEX), where funds are invested upfront and depreciated over time, generating returns from long-term assets. Meanwhile, MROI treats marketing spend as operational expenditure (OPEX), expensed immediately in the current period rather than capitalized.

MROI divides incremental profit contribution after marketing costs by the full spend, ignoring asset depreciation since marketing does not create lasting balance sheet items. Traditional ROI, however, uses assets tied up in balance sheets, enabling residual income calculations that factor the minimum required returns on those assets. 

 

Why marketing ROI matters?

Marketing ROI illustrates how the company’s marketing is performing and its impact on the business. When MROI data shows which marketing channels are most effective and most profitable, companies can pivot their marketing spend to focus on those channels and reach more customers. The ability to quickly and clearly determine the most effective marketing tactics and channels is particularly important for SMEs, where budgets are more constrained, and value needs to be proven as fast as possible.

For C-suite executives, especially CMOs and CFOs, marketing ROI provides the financial justification for continued investment. For marketing teams, it offers the language and metrics to communicate value in terms that resonate throughout the organization and to facilitate cross-team collaboration.

In conclusion, mastering MROI empowers startups to navigate tight budgets with precision, transforming lean tactics, such as SEO, social media virality, and content marketing, into scalable growth engines that deliver measurable profits.

Unlike traditional ROI, which handles long-term capital assets depreciated over time, MROI treats marketing as immediate operational expenses, emphasizing short-term incremental gains without balance sheet complications. This distinction empowers faster pivots, sharper budget decisions, and stronger alignment between marketing and finance leaders.

Ultimately, startups that prioritize MROI foster a cycle of continuous optimization, which includes auditing campaigns regularly, relocating to top performers, and scaling what works. This not only justifies marketing's role to executives but also drives lasting customer acquisition, retention, and business success in competitive landscapes.

The Rise of Saudi Biotech: Startups Driving the Kingdom’s HealthTech Revolution

Ghada Ismail

 

Saudi Arabia’s push to diversify its economy under Vision 2030 has brought several sectors into sharp focus, but few are as strategically significant as biotechnology. Once viewed largely as a research-driven niche, biotech has now become a national priority—one that sits at the intersection of healthcare resilience, economic diversification, food security, and advanced manufacturing. At the heart of this shift is a growing cohort of startups working to translate scientific research into scalable, locally relevant solutions.

While Saudi Arabia’s biotech startup ecosystem remains relatively young compared to established global hubs, momentum is building quickly. Government-backed accelerators, evolving regulatory frameworks, and stronger collaboration between academia, hospitals, and industry are laying the foundations for a homegrown life sciences sector with regional—and potentially global—reach.

 

Why Biotech Matters to Saudi Arabia

Biotechnology holds a unique position in Saudi Arabia’s long-term economic planning. Beyond innovation, it addresses structural national challenges. The Kingdom faces a high prevalence of chronic conditions such as diabetes, cardiovascular disease, and inherited disorders, while remaining heavily dependent on imported pharmaceuticals and biologics—an exposure highlighted during recent global supply chain disruptions.

In response, Saudi Arabia launched its National Biotechnology Strategy in January 2024, aiming to localize biopharmaceutical manufacturing, strengthen research and development capabilities, and attract global partnerships. Closely aligned with Vision 2030, the strategy supports broader goals, including knowledge transfer, high-value job creation, and non-oil GDP growth.

Startups play a central role within this framework. Unlike large pharmaceutical companies, early-stage ventures are inherently agile, able to experiment with novel technologies and address niche or underserved health needs. In Saudi Arabia, many are focusing on solutions tailored to regional disease profiles, giving them both local relevance and long-term competitive potential.

 

The Rise of Saudi Biotech Startups

Although still limited in number, Saudi biotech startups are expanding rapidly in scope, spanning diagnostics, therapeutics, genomics, regenerative medicine, and antimicrobial innovation. Many have emerged from university research environments or were founded by Saudi scientists returning from abroad with international experience.

One of the most closely watched areas is diabetes innovation, driven by the Kingdom’s high disease prevalence and the strategic need to localize essential treatments. Plansulin, a Riyadh-based startup founded in 2020, is developing plant-based insulin as an alternative to conventional biologics manufacturing. By using plants as biofactories, the company aims to reduce production costs, lower environmental impact, and improve the sustainability of insulin supply. Plansulin is part of the inaugural cohort of startups selected for the Ministry of Health’s Biotech Accelerator, reflecting its alignment with national healthcare and innovation priorities.

Another startup attracting attention is cellNUA, which operates at the intersection of nanomedicine and immunotherapy. The Saudi arm of the Ireland-based company draws inspiration from natural immune mechanisms—particularly those found in honeybees—to inform its therapeutic development. Through its Beemar platform, cellNUA explores comparative genomics and bio-inspired nanomolecules to develop next-generation vaccines, antivirals, and immune-modulating therapies. While still in early development stages, the company exemplifies the type of science-driven innovation policymakers are keen to nurture.

Vaccine development is also gaining traction. SAGEbio is working on next-generation vaccine and therapeutic protein platforms designed to improve efficacy and scalability. Its novel antigen platform, co-developed with King Abdullah University of Science and Technology (KAUST), aims to enhance vaccine manufacturing and delivery. The startup’s lead COVID-19 vaccine candidate is advancing toward Phase 1 clinical trials, highlighting efforts to build local capabilities for future pandemic preparedness.

 

Genomics and Precision Medicine Take Center Stage

Genomics has emerged as one of Saudi Arabia’s most promising biotech verticals, supported by initiatives such as the Saudi Genome Program, which is building one of the region’s largest population-specific genetic databases. This infrastructure is creating fertile ground for startups focused on precision diagnostics and personalized medicine.

Novo Genomics, founded in 2022, is one such company. Based in Riyadh, it specializes in advanced genetic diagnostics, including circulating tumor DNA testing and polygenic risk scoring tailored to Saudi and Middle Eastern populations. By grounding its technology in local genomic data, Novo Genomics addresses a key limitation of imported diagnostic tools that are often trained on non-representative datasets.

Similarly, NanoPalm is developing advanced delivery technologies, including lipid nanoparticle systems that improve the effectiveness of genetic and RNA-based therapies. As global biotech increasingly shifts toward gene-based treatments, delivery mechanisms have become as critical as the therapies themselves, making NanoPalm’s focus particularly timely.

Early detection is another growing focus. KaRama Bio is working on early-stage disease detection technologies, reflecting a broader shift toward preventive and predictive healthcare. Early diagnosis remains one of the most effective ways to reduce long-term healthcare costs and improve patient outcomes, particularly in oncology and chronic disease management.

 

Regenerative Medicine and Novel Therapeutics

Beyond diagnostics, Saudi biotech startups are also exploring regenerative medicine and alternative therapeutic approaches. MammoStem focuses on stem cell-based solutions aimed at tissue regeneration and recovery, particularly following surgical or chronic conditions. While regenerative medicine is complex and heavily regulated, it holds significant long-term potential as populations age and demand for restorative therapies increases.

Antimicrobial resistance represents another strategic frontier. With antibiotic resistance widely recognized as a global health threat, PhageTech is developing bacteriophage-based solutions as alternatives to conventional antibiotics. Although phage therapy remains relatively niche, renewed global interest suggests that local innovation in this space could position Saudi Arabia as a regional leader.

 

Building the Ecosystem: Accelerators and Institutions

Biotech startups do not operate in isolation, and Saudi Arabia has begun addressing one of the sector’s biggest barriers: ecosystem support. A major milestone was the launch of the Kingdom’s first dedicated Biotech Accelerator by the Ministry of Health in partnership with global life sciences incubator BioLabs. Announced at the BIO International Convention, the accelerator provides mentorship, lab access, commercialization guidance, and global networking opportunities.

Earlier-stage support has also come from the Badir Biotechnology Incubator, under King Abdulaziz City for Science and Technology (KACST), which has played a foundational role in translating research into viable biotech companies through funding, technical support, and industry connections.

Complementing these initiatives, Dammam Valley launched its Biotech Startups Programme to bridge the gap between research and commercialization. Developed in partnership with Imam Abdulrahman bin Faisal University, Saudi Aramco, multiple ministries, the Future Investment Initiative Institute, and Sadara Petrochemical Company, the program supports startup creation, technology localization, and access to investment aligned with the National Biotechnology Strategy.

On the manufacturing front, Saudi Biotechnology Manufacturing Company (SaudiBio) is laying the groundwork for scalable biopharmaceutical production. The company operates the Kingdom’s first GMP-certified sterile fill-and-finish facility for biologics, including insulin and biosimilars, enabling startups to transition from lab-scale innovation to commercial readiness.

Private capital is also beginning to play a larger role. Founded in 2024, Biotech Innovations Co (BIC) represents a new wave of private-sector investment into biologics, vaccines, and gene therapy R&D, helping anchor startups within a broader industrial value chain.

 

Regulatory Progress and Remaining Challenges

Despite rapid progress, Saudi Arabia’s biotech ecosystem still faces structural challenges. Biotechnology is capital-intensive, with long development timelines and complex regulatory requirements. Access to late-stage funding, particularly for clinical trials, remains limited, and navigating approvals can be challenging for first-time founders. Talent availability is another constraint, as advanced biotech R&D requires specialized expertise that is still developing locally.

These challenges, however, are not unique to Saudi Arabia. What distinguishes the Kingdom is the scale of state commitment to addressing them through coordinated policy, funding, and international collaboration.

 

Looking Ahead: From Emerging Market to Regional Hub

Saudi Arabia’s biotech startup scene may still be emerging, but its trajectory is clear. With strong government backing, growing private-sector involvement, and a focus on locally relevant health challenges, the Kingdom is laying the foundations for a sustainable life sciences economy.

Over the next decade, success will depend on startups’ ability to scale, attract long-term investment, and integrate into global biotech value chains. If these conditions are met, Saudi Arabia could evolve from a consumer of biotechnology into a regional—and eventually global—contributor to life sciences innovation.

In that sense, biotech startups represent more than another Vision 2030 initiative. They signal a deeper shift in how the Kingdom approaches health, science, and economic resilience.

When Industry Grows, So Does a Nation

By Dr. Mohanad AlShaikh

CEO, Johnson Controls Arabia

 

Saudi Arabia’s industrial sector continues to stretch its wings, and the recent robust performance in October is a clear signal that the Kingdom’s economic transformation is succeeding in both depth and direction. According to official data from the Ministry of Industry and Mineral Resources, 95 new industrial licenses were issued in October 2025, representing more than SR 2.4 billion in planned investment. Meanwhile, 81 factories moved into actual production with about SR 1.3 billion in investment and nearly 2,000 new jobs created, a testament to momentum at the grassroots of the non‑oil economy.

 

This growth matters far beyond the numbers themselves. It shows that Saudi Arabia’s strategy to re-engineer its industrial landscape is working, not just in broad ambition, but in real factories, real jobs, and real economic impact. At the heart of this transformation is Vision 2030’s call for localization, empowered talent, and export-ready production. The idea is simple yet profound: a country that makes what it uses and exports what it makes gives its people sovereignty in their livelihoods and its economy greater resilience. Growing industrial output and factory activation are essential steps in creating a manufacturing base that can compete regionally and internationally.

 

I witnessed this momentum firsthand during the Ministry of Industry and Mineral Resources’ Standardized Incentives for the Manufacturing Sector event recently in Riyadh, where an official signing ceremony was held to award incentives to select manufacturers. Johnson Controls Arabia was honored to be among the recipients, with a project focused on localizing production of advanced water-cooled centrifugal chillers.

 

His Excellency Bandar Alkhorayef, Minister of Industry and Mineral Resources, opened the event by announcing that SR 2 billion has been earmarked to support new and expanding factories across the Kingdom. His speech was followed by mine, where I shared a belief deeply held across our company:

“A country that manufactures is a country that holds its destiny in its own hands.”

 

This vision is moving from words to implementation and the results are visible not only in industrial licensing and factory activation but also in trade performance. Saudi Arabia’s non-oil exports reached a record SAR 307 billion in the first half of 2025, marking the highest level in the Kingdom’s history. This achievement underscores the link between industrial growth and global competitiveness: every new factory and every localized product strengthen the Kingdom’s ability to compete internationally.

 

Localization is a foundation for scale, quality, and global relevance, never a move toward isolation. A product labeled “Made in Saudi” becomes more than an economic input. It becomes a statement of national capability. The ability to export high-value, high-quality Saudi products is essential to the Kingdom’s ambitions to expand its role among the world’s industrial powers.

 

As the Kingdom sets its sights on elevating its global industrial standing, this kind of growth and investment is not just a metric of success, it’s a strategic necessity. Industrialization supports diversification, anchors value chains, and enables the very sovereignty that Vision 2030 envisions.

 

When factories expand, licenses multiply, and production lines hum with activity, we witness a nation accelerating toward a future it is building with its own hands.